Vaginal progesterone for preventing preterm birth and adverse perinatal outcomes in singleton gestations with a short cervix: a meta-analysis of individual patient data

R Romero, A Conde-Agudelo, E Da Fonseca… - American journal of …, 2018 - Elsevier
Background The efficacy of vaginal progesterone for preventing preterm birth and adverse
perinatal outcomes in singleton gestations with a short cervix has been questioned after
publication of the OPPTIMUM study. Objective To determine whether vaginal progesterone
prevents preterm birth and improves perinatal outcomes in asymptomatic women with a
singleton gestation and a midtrimester sonographic short cervix. Study Design We searched
MEDLINE, EMBASE, LILACS, and CINAHL (from their inception to September 2017); …