Progesterone suppresses the fetal inflammatory response ex vivo
N Schwartz, X Xue, MA Elovitz, O Dowling… - American journal of …, 2009 - Elsevier
OBJECTIVE: Progesterone supplementation has been shown to be efficacious in preventing
preterm birth. We sought to investigate the effects of progesterone on fetal inflammatory
responses. STUDY DESIGN: Fetal mononuclear cells were isolated from umbilical cord
blood and exposed to vehicle or progesterone (P4) for 1 hour prior to lipopolysaccharide
(LPS) stimulation. Supernatants were assayed for tumor necrosis factor-α. Similar
experiments were performed using cyclic adenosine monophosphate (cAMP) and …
preterm birth. We sought to investigate the effects of progesterone on fetal inflammatory
responses. STUDY DESIGN: Fetal mononuclear cells were isolated from umbilical cord
blood and exposed to vehicle or progesterone (P4) for 1 hour prior to lipopolysaccharide
(LPS) stimulation. Supernatants were assayed for tumor necrosis factor-α. Similar
experiments were performed using cyclic adenosine monophosphate (cAMP) and …
