[HTML][HTML] Lack of association of human leukocyte antigen-B7 with COPD and rate of decline in lung function
I Kasuga, J Ruan, JE Connett, NR Anthonisen… - Respiratory …, 2005 - Elsevier
I Kasuga, J Ruan, JE Connett, NR Anthonisen, AJ Sandford
Respiratory medicine, 2005•ElsevierBackground: Although variation in the human leukocyte antigen (HLA) locus is associated
with various diseases, there have been a limited number of studies that have examined the
possible role of HLA in chronic obstructive pulmonary disease (COPD). Only HLA-B7 has
been shown to be correlated with low forced expiratory volume in 1s (FEV1) in Caucasians;
however, this finding has not been replicated. The aim of this study was to investigate the
contribution of the HLA-B7 allele to COPD and to rate of decline of lung function. Methods …
with various diseases, there have been a limited number of studies that have examined the
possible role of HLA in chronic obstructive pulmonary disease (COPD). Only HLA-B7 has
been shown to be correlated with low forced expiratory volume in 1s (FEV1) in Caucasians;
however, this finding has not been replicated. The aim of this study was to investigate the
contribution of the HLA-B7 allele to COPD and to rate of decline of lung function. Methods …
Background
Although variation in the human leukocyte antigen (HLA) locus is associated with various diseases, there have been a limited number of studies that have examined the possible role of HLA in chronic obstructive pulmonary disease (COPD). Only HLA-B7 has been shown to be correlated with low forced expiratory volume in 1s (FEV1) in Caucasians; however, this finding has not been replicated. The aim of this study was to investigate the contribution of the HLA-B7 allele to COPD and to rate of decline of lung function.
Methods
We determined the prevalence of HLA-B7 in a group of COPD patients and a non-obstructed control group of smokers by using a polymerase chain reaction-based genotyping assay. We also determined the prevalence of HLA-B7 in smokers selected from the National Heart Lung and Blood Institute, Lung Health Study for having the fastest and slowest decline of lung function.
Results
No significant difference was found in the frequency of HLA-B7 between the COPD and non-obstructed groups. There was also no significant association of HLA-B7 with rate of decline of lung function.
Conclusion
These data indicate that HLA-B7 does not contribute to COPD or rate of decline of FEV1 in smokers.
Elsevier
