[HTML][HTML] Elevated MUC1 and MUC5AC mucin protein levels in airway mucus of critical ill COVID‐19 patients

W Lu, X Liu, T Wang, F Liu, A Zhu, Y Lin… - Journal of Medical …, 2021 - ncbi.nlm.nih.gov
W Lu, X Liu, T Wang, F Liu, A Zhu, Y Lin, J Luo, F Ye, J He, J Zhao, Y Li, N Zhong
Journal of Medical Virology, 2021ncbi.nlm.nih.gov
Patients with coronavirus disease 2019 (COVID‐19) exhibit a spectrum of respiratory
symptoms like cough and dyspnea. 1‐3 Airway mucus is an adhesive viscoelastic gel
composed mostly of high‐molecular‐weight mucous glycoproteins and water, which is
important in maintaining lung function and health, pathological mucus hypersecretion may
cause airway obstruction and lead to respiratory distress. Mucin (MUC) glycoproteins are the
major macromolecular components of mucus, which are classified into two major types: the …
Patients with coronavirus disease 2019 (COVID‐19) exhibit a spectrum of respiratory symptoms like cough and dyspnea. 1‐3 Airway mucus is an adhesive viscoelastic gel composed mostly of high‐molecular‐weight mucous glycoproteins and water, which is important in maintaining lung function and health, pathological mucus hypersecretion may cause airway obstruction and lead to respiratory distress. Mucin (MUC) glycoproteins are the major macromolecular components of mucus, which are classified into two major types: the gel‐forming secreted MUC5AC and the membrane‐tethered MUC1. 4 Here, with an attempt to understand the lung changes, we sought to provide a delineation of the components of airway mucus from patients with COVID‐19.
To clean airway obstruction, respiratory tract mucus was aspirated and collected via bronchoscopy from COVID‐19 patients with a critical illness, and optical coherence tomography (OCT) was applied via bronchoscopy to obtain cross‐sectional images of the bronchiole. For healthy control, sputum was induced by inhaled hypertonic (3%) saline solution delivered with an ultrasonic nebulizer. After collection, sputum was processed as previously described for components analysis. 5 Medical history, and clinical and laboratory data of the participants were extracted from electronic medical records.
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