Specificity, kinetics and longevity of antibody responses to avian influenza A (H7N9) virus infection in humans

J Chen, H Zhu, PW Horby, Q Wang, J Zhou, H Jiang… - Journal of Infection, 2020 - Elsevier
Objectives The long-term dynamics of antibody responses in patients with influenza A
(H7N9) virus infection are not well understood. Methods We conducted a longitudinal
serological follow-up study in patients who were hospitalized with A (H7N9) virus infection,
during 2013–2018. A (H7N9) virus-specific antibody responses were assessed by
hemagglutination inhibition (HAI) and neutralization (NT) assays. A random intercept model
was used to fit a curve to HAI antibody responses over time. HAI antibody responses were …