Frameshift mutation of a histone methylation-related gene SETD1B and its regional heterogeneity in gastric and colorectal cancers with high microsatellite instability
YJ Choi, HR Oh, MR Choi, M Gwak, CH An, YJ Chung… - Human pathology, 2014 - Elsevier
Histone methyltransferase (HMT), which catalyzes a histone methylation, is frequently
altered in cancers at mutation and expression levels. The aims of this study were to explore
whether SETD1B, SETDB2, and SETD2, SET domain–containing HMT genes, are mutated
and expressionally altered in gastric (GC) and colorectal cancers (CRC). In a public
database, we found that SETD1B, SETDB2, and SETD2 had mononucleotide repeats in
coding sequences that might be mutation targets in cancers with microsatellite instability …
altered in cancers at mutation and expression levels. The aims of this study were to explore
whether SETD1B, SETDB2, and SETD2, SET domain–containing HMT genes, are mutated
and expressionally altered in gastric (GC) and colorectal cancers (CRC). In a public
database, we found that SETD1B, SETDB2, and SETD2 had mononucleotide repeats in
coding sequences that might be mutation targets in cancers with microsatellite instability …