Parathyroid carcinoma can be difficult to diagnose, and the final pathologic diagnosis relies
on clinicopathologic correlation. Clinical features of malignancy include high preoperative
calcium levels and an intraoperative impression that the gland is adherent to local
structures. Histologic features of malignancy include increased mitoses, vascular invasion,
and broad bands of fibrosis. This study used molecular genotyping to assess parathyroid
neoplasia for loss of heterozygosity across a panel of known tumor suppressor genes that …