Anti-factor B and anti-C3b autoantibodies in C3 glomerulopathy and Ig-associated membranoproliferative GN
MC Marinozzi, LT Roumenina, S Chauvet… - Journal of the …, 2017 - journals.lww.com
Abstract In C3 glomerulopathy (C3G), the alternative pathway of complement is frequently
overactivated by autoantibodies that stabilize the C3 convertase C3bBb. Anti-C3b and anti-
factor B (anti-FB) IgG have been reported in three patients with C3G. We screened a cohort
of 141 patients with C3G and Ig-associated membranoproliferative GN (Ig-MPGN) for anti-FB
and anti-C3b autoantibodies using ELISA. We identified seven patients with anti-FB IgG,
three patients with anti-C3b IgG, and five patients with anti-FB and anti-C3b IgG. Of these 15 …
overactivated by autoantibodies that stabilize the C3 convertase C3bBb. Anti-C3b and anti-
factor B (anti-FB) IgG have been reported in three patients with C3G. We screened a cohort
of 141 patients with C3G and Ig-associated membranoproliferative GN (Ig-MPGN) for anti-FB
and anti-C3b autoantibodies using ELISA. We identified seven patients with anti-FB IgG,
three patients with anti-C3b IgG, and five patients with anti-FB and anti-C3b IgG. Of these 15 …