Rodent obesity models: an overview
Animal obesity models differ widely in type and extent of obesity. They are either based on
environmental factors (eg. high fat diet induced obesity), spontaneous mutants (ie ob/ob
mice), genetically engineered animals (eg. mice with melanocortin receptor subtype-4 gene
disruption (knock-out)) or mechanical intervention (eg. chemical lesion of the ventromedial
hypothalamus). This article reviews available rodent models to study obesity and attempts to
highlight the greatest utility for each model.
environmental factors (eg. high fat diet induced obesity), spontaneous mutants (ie ob/ob
mice), genetically engineered animals (eg. mice with melanocortin receptor subtype-4 gene
disruption (knock-out)) or mechanical intervention (eg. chemical lesion of the ventromedial
hypothalamus). This article reviews available rodent models to study obesity and attempts to
highlight the greatest utility for each model.
Summary
Animal obesity models differ widely in type and extent of obesity. They are either based on environmental factors (eg. high fat diet induced obesity), spontaneous mutants (ie ob/ob mice), genetically engineered animals (eg. mice with melanocortin receptor subtype-4 gene disruption (knock-out)) or mechanical intervention (eg. chemical lesion of the ventromedial hypothalamus). This article reviews available rodent models to study obesity and attempts to highlight the greatest utility for each model.
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