[HTML][HTML] Influence of the hepatic eukaryotic initiation factor 2α (eIF2α) endoplasmic reticulum (ER) stress response pathway on insulin-mediated ER stress and hepatic …
AL Birkenfeld, HY Lee, S Majumdar, MJ Jurczak… - Journal of Biological …, 2011 - ASBMB
Recent studies have implicated endoplasmic reticulum (ER) stress in insulin resistance
associated with caloric excess. In mice placed on a 3-day high fat diet, we find augmented
eIF2α signaling, together with hepatic lipid accumulation and insulin resistance. To clarify
the role of the liver ER stress-dependent phospho-eIF2α (eIF2α-P) pathway in response to
acute caloric excess on liver and muscle glucose and lipid metabolism, we studied
transgenic mice in which the hepatic ER stress-dependent eIF2α-P pathway was inhibited …
associated with caloric excess. In mice placed on a 3-day high fat diet, we find augmented
eIF2α signaling, together with hepatic lipid accumulation and insulin resistance. To clarify
the role of the liver ER stress-dependent phospho-eIF2α (eIF2α-P) pathway in response to
acute caloric excess on liver and muscle glucose and lipid metabolism, we studied
transgenic mice in which the hepatic ER stress-dependent eIF2α-P pathway was inhibited …