Sterol-dependent regulation of proprotein convertase subtilisin/kexin type 9 expression by sterol-regulatory element binding protein-2s⃞
HJ Jeong, HS Lee, KS Kim, YK Kim, D Yoon… - Journal of lipid …, 2008 - ASBMB
Proprotein convertase subtilisin/kexin type 9 (PCSK9) is a member of the subtilases that
promotes the internalization and degradation of LDL receptor in liver and thereby controls
the level of LDL cholesterol in plasma. Here, we show that the expression of PCSK9 in
HepG2 cells is completely dependent on the absence or presence of sterols. The minimal
promoter region of the PCSK9 gene contains a sterol-regulatory element (SRE), which
makes the transcription of PCSK9 dependent on sterols. Expression of nuclear forms of …
promotes the internalization and degradation of LDL receptor in liver and thereby controls
the level of LDL cholesterol in plasma. Here, we show that the expression of PCSK9 in
HepG2 cells is completely dependent on the absence or presence of sterols. The minimal
promoter region of the PCSK9 gene contains a sterol-regulatory element (SRE), which
makes the transcription of PCSK9 dependent on sterols. Expression of nuclear forms of …
