The LDL receptor
JL Goldstein, MS Brown - Arteriosclerosis, thrombosis, and …, 2009 - Am Heart Assoc
JL Goldstein, MS Brown
Arteriosclerosis, thrombosis, and vascular biology, 2009•Am Heart AssocIn this article, the history of the LDL receptor is recounted by its codiscoverers. Their early
work on the LDL receptor explained a genetic cause of heart attacks and led to new ways of
thinking about cholesterol metabolism. The LDL receptor discovery also introduced three
general concepts to cell biology: receptor-mediated endocytosis, receptor recycling, and
feedback regulation of receptors. The latter concept provides the mechanism by which
statins selectively lower plasma LDL, reducing heart attacks and prolonging life.
work on the LDL receptor explained a genetic cause of heart attacks and led to new ways of
thinking about cholesterol metabolism. The LDL receptor discovery also introduced three
general concepts to cell biology: receptor-mediated endocytosis, receptor recycling, and
feedback regulation of receptors. The latter concept provides the mechanism by which
statins selectively lower plasma LDL, reducing heart attacks and prolonging life.
In this article, the history of the LDL receptor is recounted by its codiscoverers. Their early work on the LDL receptor explained a genetic cause of heart attacks and led to new ways of thinking about cholesterol metabolism. The LDL receptor discovery also introduced three general concepts to cell biology: receptor-mediated endocytosis, receptor recycling, and feedback regulation of receptors. The latter concept provides the mechanism by which statins selectively lower plasma LDL, reducing heart attacks and prolonging life.
Am Heart Assoc