[HTML][HTML] Asialoglycoprotein receptor 1 gene expression in peripheral blood monocytes associates with serum total cholesterol and low-density lipoprotein cholesterol …

X Zhao, B Tang, ZH Shi, ZW Deng, Y Deng… - Chinese Medical …, 2020 - mednexus.org
X Zhao, B Tang, ZH Shi, ZW Deng, Y Deng, LM Tan, SL Jiang, YL Shu, CF Qiu
Chinese Medical Journal, 2020mednexus.org
To the Editor: Asialoglycoprotein receptor 1 (ASGR1) is the major subunit of ASGR, it is
predominantly expressed by liver parenchymal cells and relatively lower expression was
found in peripheral blood monocytes.[1] A genetic study recently revealed that ASGR1
haploinsufficiency resulted from loss-of-function (LOF) variants was strongly associated with
the pronounced reductions in serum total cholesterol (TC) and low-density lipoprotein
cholesterol (LDL-C) levels,[2, 3] suggesting that ASGR1 may play a key role in cholesterol …
To the Editor: Asialoglycoprotein receptor 1 (ASGR1) is the major subunit of ASGR, it is predominantly expressed by liver parenchymal cells and relatively lower expression was found in peripheral blood monocytes.[1] A genetic study recently revealed that ASGR1 haploinsufficiency resulted from loss-of-function (LOF) variants was strongly associated with the pronounced reductions in serum total cholesterol (TC) and low-density lipoprotein cholesterol (LDL-C) levels,[2, 3] suggesting that ASGR1 may play a key role in cholesterol metabolism. However, the function of ASGR1 remains largely unclear. This study was focused on the association of ASGR1 gene expression in monocytes and plasma cholesterol level.
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