Increase of B cell-activating factor of the TNF family (BAFF) after rituximab treatment: insights into a new regulating system of BAFF production
F Lavie, C Miceli-Richard, M Ittah, J Sellam… - Annals of the rheumatic …, 2007 - Elsevier
Background The cytokine B cell-activating factor of the TNF family (BAFF) is involved in the
pathogenesis of autoimmune diseases. Objective To access changes in serum protein and
mRNA levels of BAFF after rituximab treatment. Methods Serum and peripheral blood
mononuclear cells (PBMCs) were isolated from five patients (two with lupus, two with
Sjögren's syndrome, one with rheumatoid arthritis) before and 12 weeks (range 7–17) after a
first course of rituximab infusion. Monocytes and B cells were selected from healthy controls …
pathogenesis of autoimmune diseases. Objective To access changes in serum protein and
mRNA levels of BAFF after rituximab treatment. Methods Serum and peripheral blood
mononuclear cells (PBMCs) were isolated from five patients (two with lupus, two with
Sjögren's syndrome, one with rheumatoid arthritis) before and 12 weeks (range 7–17) after a
first course of rituximab infusion. Monocytes and B cells were selected from healthy controls …