The RAG recombinase: beyond breaking
C Lescale, L Deriano - Mechanisms of Ageing and Development, 2017 - Elsevier
DNA double-strand breaks (DSBs) are commonly seen as lesions that threaten genome
integrity and contribute to cancer and aging processes. However, in the context of antigen
receptor gene assembly, known as V (D) J recombination, DSBs are obligatory
intermediates that allow the establishment of genetic diversity and adaptive immunity. V (D)
J recombination is initiated when the lymphoid-restricted recombination-activating genes
RAG1 and RAG2 are expressed and form a site-specific endonuclease (the RAG nuclease …
integrity and contribute to cancer and aging processes. However, in the context of antigen
receptor gene assembly, known as V (D) J recombination, DSBs are obligatory
intermediates that allow the establishment of genetic diversity and adaptive immunity. V (D)
J recombination is initiated when the lymphoid-restricted recombination-activating genes
RAG1 and RAG2 are expressed and form a site-specific endonuclease (the RAG nuclease …
