Determining γδ versus αβ T cell development
M Ciofani, JC Zúñiga-Pflücker - Nature Reviews Immunology, 2010 - nature.com
Nature Reviews Immunology, 2010•nature.com
The thymus produces several types of functionally distinct T cell subsets. However, at a more
fundamental level only two genetically distinct T cell lineages exist: the γδ and αβ T cell
lineages. Precisely how these two T cell lineages are generated from common thymocyte
progenitor cells remains to be fully elucidated and is under intense investigation. Here, we
highlight recent findings that have helped to provide important clues to the mechanisms that
underpin the generation of γδ T cells in the mouse thymus.
fundamental level only two genetically distinct T cell lineages exist: the γδ and αβ T cell
lineages. Precisely how these two T cell lineages are generated from common thymocyte
progenitor cells remains to be fully elucidated and is under intense investigation. Here, we
highlight recent findings that have helped to provide important clues to the mechanisms that
underpin the generation of γδ T cells in the mouse thymus.
Abstract
The thymus produces several types of functionally distinct T cell subsets. However, at a more fundamental level only two genetically distinct T cell lineages exist: the γδ and αβ T cell lineages. Precisely how these two T cell lineages are generated from common thymocyte progenitor cells remains to be fully elucidated and is under intense investigation. Here, we highlight recent findings that have helped to provide important clues to the mechanisms that underpin the generation of γδ T cells in the mouse thymus.
nature.com
