A double-negative (IgD− CD27−) B cell population is increased in the peripheral blood of elderly people
G Colonna-Romano, M Bulati, A Aquino… - Mechanisms of ageing …, 2009 - Elsevier
The T cell branch of the immune system has been extensively studied in the elderly and it is
known that the elderly have impaired immune function, mainly due to the chronic antigenic
load that ultimately causes shrinkage of the T cell repertoire and filling of the immunologic
space with memory T cells. In the present paper, we describe the IgD− CD27− double-
negative B cell population which (as we have recently described) is higher in the elderly.
Most of these cells were IgG+. Evaluation of the telomere length and expression of the …
known that the elderly have impaired immune function, mainly due to the chronic antigenic
load that ultimately causes shrinkage of the T cell repertoire and filling of the immunologic
space with memory T cells. In the present paper, we describe the IgD− CD27− double-
negative B cell population which (as we have recently described) is higher in the elderly.
Most of these cells were IgG+. Evaluation of the telomere length and expression of the …