Mechanism and control of V (D) J recombination at the immunoglobulin heavy chain locus
D Jung, C Giallourakis, R Mostoslavsky… - Annu. Rev …, 2006 - annualreviews.org
Abstract V (D) J recombination assembles antigen receptor variable region genes from
component germline variable (V), diversity (D), and joining (J) gene segments. For B cells,
such rearrangements lead to the production of immunoglobulin (Ig) proteins composed of
heavy and light chains. V (D) J is tightly controlled at the Ig heavy chain locus (IgH) at
several different levels, including cell-type specificity, intra-and interlocus ordering, and
allelic exclusion. Such controls are mediated at the level of gene segment accessibility to V …
component germline variable (V), diversity (D), and joining (J) gene segments. For B cells,
such rearrangements lead to the production of immunoglobulin (Ig) proteins composed of
heavy and light chains. V (D) J is tightly controlled at the Ig heavy chain locus (IgH) at
several different levels, including cell-type specificity, intra-and interlocus ordering, and
allelic exclusion. Such controls are mediated at the level of gene segment accessibility to V …