[HTML][HTML] An unexpected counter-regulatory role of IL-10 in B-lymphocyte-mediated transplantation tolerance
G Zhao, DJ Moore, KM Lee, K JI, PE Duff… - American Journal of …, 2010 - Elsevier
Monoclonal antibody against the CD45RB protein induces stable transplantation tolerance
to multiple types of allograft. We have previously established that this tolerance protocol
relies on the regulatory function of B lymphocytes for its effect. B lymphocytes have also
been reported to participate in immune regulation in several other settings. In most of these
systems, the regulatory function of B lymphocytes depends on the production of IL-10.
Therefore, we investigated the role of IL-10 in the anti-CD45RB model of B-cell-mediated …
to multiple types of allograft. We have previously established that this tolerance protocol
relies on the regulatory function of B lymphocytes for its effect. B lymphocytes have also
been reported to participate in immune regulation in several other settings. In most of these
systems, the regulatory function of B lymphocytes depends on the production of IL-10.
Therefore, we investigated the role of IL-10 in the anti-CD45RB model of B-cell-mediated …