Cyclosporine inhibits long-term survival in cardiac allografts treated with monoclonal antibody against CD45RB
N Parry, AI Lazarovits, J Wang, B Garcia, P Luke… - The Journal of heart and …, 1999 - Elsevier
Background: We have previously reported that a monoclonal antibody to CD45RB is a novel
immunosuppressive agent; however, the optimal regimen in cardiac allografts remains
unknown. The present study was undertaken to determine the optimal protocol of this
therapy and its interaction with cyclosporine. METHODS: A heterotopic heart allograft model
was used in C57BL/6 to BALB/c mice. The following studies were conducted: 1) dose
response study (low, intermediate, and high doses at 1, 3, and 9 mg/kg/day respectively), 2) …
immunosuppressive agent; however, the optimal regimen in cardiac allografts remains
unknown. The present study was undertaken to determine the optimal protocol of this
therapy and its interaction with cyclosporine. METHODS: A heterotopic heart allograft model
was used in C57BL/6 to BALB/c mice. The following studies were conducted: 1) dose
response study (low, intermediate, and high doses at 1, 3, and 9 mg/kg/day respectively), 2) …