[HTML][HTML] Anti-CD45RB/anti-TIM-1-induced tolerance requires regulatory B cells
KM Lee, JI Kim, R Stott, J Soohoo, MR O'Connor… - American Journal of …, 2012 - Elsevier
The role of B cells in transplant tolerance remains unclear. Although B-cell depletion often
prolongs graft survival, sometimes it results in more rapid rejection, suggesting that B cells
may have regulatory activity. We previously demonstrated that tolerance induction by anti-
CD45RB antibody requires recipient B cells. Here, we show that anti-CD45RB in
combination with anti-TIM-1 antibody has a synergistic effect, inducing tolerance in all
recipients in a mouse islet allograft model. This effect depends on the presence of recipient …
prolongs graft survival, sometimes it results in more rapid rejection, suggesting that B cells
may have regulatory activity. We previously demonstrated that tolerance induction by anti-
CD45RB antibody requires recipient B cells. Here, we show that anti-CD45RB in
combination with anti-TIM-1 antibody has a synergistic effect, inducing tolerance in all
recipients in a mouse islet allograft model. This effect depends on the presence of recipient …