Interleukin-8 up-regulation by neutrophil elastase is mediated by MyD88/IRAK/TRAF-6 in human bronchial epithelium
Cystic fibrosis is characterized in the lungs by neutrophil-dominated inflammation mediated
significantly by neutrophil elastase (NE). Previous work has shown that NE induces
interleukin-8 (IL-8) gene expression and protein secretion in bronchial epithelial cells. We
sought to determine the intracellular mechanisms by which NE up-regulates IL-8 in
bronchial epithelial cells. The data show that stimulation of 16HBE14o− cells with NE
induced IL-8 protein production and gene expression. Both responses were abrogated by …
significantly by neutrophil elastase (NE). Previous work has shown that NE induces
interleukin-8 (IL-8) gene expression and protein secretion in bronchial epithelial cells. We
sought to determine the intracellular mechanisms by which NE up-regulates IL-8 in
bronchial epithelial cells. The data show that stimulation of 16HBE14o− cells with NE
induced IL-8 protein production and gene expression. Both responses were abrogated by …
