[HTML][HTML] Is COVID-19 associated thrombosis caused by overactivation of the complement cascade? A literature review
A Fletcher-Sandersjöö, BM Bellander - Thrombosis research, 2020 - Elsevier
Severe acute respiratory syndrome coronavirus 2 is responsible for the current COVID-19
pandemic resulting in an escalating number of cases and fatalities worldwide. Preliminary
evidence from these patients, as well as past coronavirus epidemics, indicates that those
infected suffer from disproportionate complement activation as well as excessive
coagulation, leading to thrombotic complications and poor outcome. In non-coronavirus
cohorts, evidence has accumulated of an interaction between the complement and …
pandemic resulting in an escalating number of cases and fatalities worldwide. Preliminary
evidence from these patients, as well as past coronavirus epidemics, indicates that those
infected suffer from disproportionate complement activation as well as excessive
coagulation, leading to thrombotic complications and poor outcome. In non-coronavirus
cohorts, evidence has accumulated of an interaction between the complement and …