[HTML][HTML] Adenoviral-mediated TGF-β1 inhibition in a mouse model of myelofibrosis inhibit bone marrow fibrosis development
T Gastinne, F Vigant, C Lavenu-Bombled… - Experimental …, 2007 - Elsevier
Myelofibrosis is characterized by excessive deposits of extracellular matrix proteins, which
occur as a marrow microenvironment reactive response to cytokines released from the
clonal malignant myeloproliferation. The observation that mice exposed to high systemic
levels of thrombopoietin (TPO) invariably developing myelofibrosis has allowed
demonstration of the crucial role of transforming growth factor (TGF)-β1 released by
hematopoietic cells in the onset of myelofibrosis. The purpose of this study was to …
occur as a marrow microenvironment reactive response to cytokines released from the
clonal malignant myeloproliferation. The observation that mice exposed to high systemic
levels of thrombopoietin (TPO) invariably developing myelofibrosis has allowed
demonstration of the crucial role of transforming growth factor (TGF)-β1 released by
hematopoietic cells in the onset of myelofibrosis. The purpose of this study was to …