[HTML][HTML] Modulation of Smad2-mediated signaling by extracellular signal-regulated kinase
M Funaba, CM Zimmerman, LS Mathews - Journal of Biological Chemistry, 2002 - ASBMB
Components of the transforming growth factor-β and mitogen-activated protein kinase
pathways interact in controlling cell growth and differentiation. We show that
phosphorylation of Smad2, a mediator of the activin/transforming growth factor-β signal, by
activated extracellular signal-regulated kinase 1 (ERK1) increases the amount of Smad2
protein and leads to enhanced transcriptional activity. Epidermal growth factor increased
phosphorylation of Smad2 in COS7 cells, and Smad2-dependent transcription in a mink …
pathways interact in controlling cell growth and differentiation. We show that
phosphorylation of Smad2, a mediator of the activin/transforming growth factor-β signal, by
activated extracellular signal-regulated kinase 1 (ERK1) increases the amount of Smad2
protein and leads to enhanced transcriptional activity. Epidermal growth factor increased
phosphorylation of Smad2 in COS7 cells, and Smad2-dependent transcription in a mink …