[HTML][HTML] Quantitation of fixative-induced morphologic and antigenic variation in mouse and human breast cancers
RD Cardiff, NE Hubbard, JA Engelberg, RJ Munn… - Laboratory …, 2013 - Elsevier
Abstract Quantitative Image Analysis (QIA) of digitized whole slide images for morphometric
parameters and immunohistochemistry of breast cancer antigens was used to evaluate the
technical reproducibility, biological variability, and intratumoral heterogeneity in three
transplantable mouse mammary tumor models of human breast cancer. The relative
preservation of structure and immunogenicity of the three mouse models and three human
breast cancers was also compared when fixed with representatives of four distinct classes of …
parameters and immunohistochemistry of breast cancer antigens was used to evaluate the
technical reproducibility, biological variability, and intratumoral heterogeneity in three
transplantable mouse mammary tumor models of human breast cancer. The relative
preservation of structure and immunogenicity of the three mouse models and three human
breast cancers was also compared when fixed with representatives of four distinct classes of …