MicroRNA-150 inhibits expression of adiponectin receptor 2 and is a potential therapeutic target in patients with chronic heart failure
S Kreth, C Ledderose, S Schütz, A Beiras… - The Journal of Heart and …, 2014 - Elsevier
Background Adiponectin is an anti-inflammatory adipocytokine believed to be involved in
the pathogenesis of chronic heart failure (CHF). We aimed to characterize the expression of
adiponectin and its receptors in CHF and to assess the impact of microRNAs on the cardiac
adiponectin system. Methods Expression of adiponectin and adiponectin receptors
(ADIPOR1 and ADIPOR2) was studied by qPCR and immunohistochemistry in myocardial
tissues of patients with end-stage CHF and control subjects. MicroRNA binding was …
the pathogenesis of chronic heart failure (CHF). We aimed to characterize the expression of
adiponectin and its receptors in CHF and to assess the impact of microRNAs on the cardiac
adiponectin system. Methods Expression of adiponectin and adiponectin receptors
(ADIPOR1 and ADIPOR2) was studied by qPCR and immunohistochemistry in myocardial
tissues of patients with end-stage CHF and control subjects. MicroRNA binding was …