Tissue factor expressed by neutrophils: another piece in the vascular inflammation puzzle

N Maugeri, AA Manfredi - Seminars in Thrombosis and …, 2015 - thieme-connect.com
N Maugeri, AA Manfredi
Seminars in Thrombosis and Hemostasis, 2015thieme-connect.com
The transition from the classic role of neutrophils as the first line of defense of the immune
system to that of physiological regulators of intravascular thrombosis took nearly three
decades to emerge. This transition needed time to unravel the complex links between the
mechanisms that regulate hemostasis and inflammation and the innate immune response,
multicellular and multifactorial processes that interact with each other. The present review is
focused on the expression of tissue factor by neutrophils, a critical event in their …
The transition from the classic role of neutrophils as the first line of defense of the immune system to that of physiological regulators of intravascular thrombosis took nearly three decades to emerge. This transition needed time to unravel the complex links between the mechanisms that regulate hemostasis and inflammation and the innate immune response, multicellular and multifactorial processes that interact with each other. The present review is focused on the expression of tissue factor by neutrophils, a critical event in their inflammatory and thrombotic function.
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