Direct effects of nutrients, acetylcholine, CCK, and insulin on ghrelin release from the isolated stomachs of rats
YB Shrestha, K Wickwire, SQ Giraudo - Peptides, 2009 - Elsevier
Ghrelin is a powerful orexigenic peptide predominantly secreted by the stomach. Blood
concentration of ghrelin increases before meals and fall postprandial. Its regulation appears
to be influenced by the type of macronutrient ingested, the vagus nerve stimulation and by
other post-meal stimulated hormonal factors. However, the direct role of nutrients (amino
acids or lipids), neuronal (vagal neurotransmitter acetylcholine) and satiety-inducing factor
such as CCK are not known. To study this we applied amino acids, lipids, acetylcholine and …
concentration of ghrelin increases before meals and fall postprandial. Its regulation appears
to be influenced by the type of macronutrient ingested, the vagus nerve stimulation and by
other post-meal stimulated hormonal factors. However, the direct role of nutrients (amino
acids or lipids), neuronal (vagal neurotransmitter acetylcholine) and satiety-inducing factor
such as CCK are not known. To study this we applied amino acids, lipids, acetylcholine and …