[HTML][HTML] Cardiac fibroblasts in pressure overload hypertrophy: the enemy within?

N Bursac - The Journal of clinical investigation, 2014 - Am Soc Clin Investig
The Journal of clinical investigation, 2014Am Soc Clin Investig
Cardiac fibroblasts have been long recognized as active participants in heart disease;
however, their exact physiological and pathological roles remain elusive, mainly due to the
lack of specific markers. In this issue of the JCI, Moore-Morris and colleagues used a
fibroblast-specific collagen1a1-GFP reporter to demonstrate that fibroblast accumulation
after aortic banding in murine hearts arises almost exclusively from proliferation of resident
fibroblasts originating from both the epicardium and a previously unrecognized source, the …
Cardiac fibroblasts have been long recognized as active participants in heart disease; however, their exact physiological and pathological roles remain elusive, mainly due to the lack of specific markers. In this issue of the JCI, Moore-Morris and colleagues used a fibroblast-specific collagen1a1-GFP reporter to demonstrate that fibroblast accumulation after aortic banding in murine hearts arises almost exclusively from proliferation of resident fibroblasts originating from both the epicardium and a previously unrecognized source, the endocardium. Further characterization of fibroblast origin and function in different types and stages of heart disease could lead to development of improved fibroblast-targeted cardiac therapies.
The Journal of Clinical Investigation