IκB kinase inhibitor attenuates sepsis-induced cardiac dysfunction in CKD
Patients with CKD requiring dialysis have a higher risk of sepsis and a 100-fold higher
mortality rate than the general population with sepsis. The severity of cardiac dysfunction
predicts mortality in patients with sepsis. Here, we investigated the effect of preexisting CKD
on cardiac function in mice with sepsis and whether inhibition of IκB kinase (IKK) reduces
the cardiac dysfunction in CKD sepsis. Male C57BL/6 mice underwent 5/6 nephrectomy, and
8 weeks later, they were subjected to LPS (2 mg/kg) or sepsis by cecal ligation and puncture …
mortality rate than the general population with sepsis. The severity of cardiac dysfunction
predicts mortality in patients with sepsis. Here, we investigated the effect of preexisting CKD
on cardiac function in mice with sepsis and whether inhibition of IκB kinase (IKK) reduces
the cardiac dysfunction in CKD sepsis. Male C57BL/6 mice underwent 5/6 nephrectomy, and
8 weeks later, they were subjected to LPS (2 mg/kg) or sepsis by cecal ligation and puncture …