Adrenomedullin (AM) and proadrenomedullin N-terminal 20 peptide (PAMP) are 2
biologically active peptides produced by the same gene, ADM, with ubiquitous distribution
and many physiological functions. Adrenomedullin is composed of 52 amino acids, has an
internal molecular ring composed by 6 amino acids and a disulfide bond, and shares
structural similarities with calcitonin gene-related peptide, amylin, and intermedin. The AM
receptor consists of a 7-transmembrane domain protein called calcitonin receptor-like …