[HTML][HTML] CD4+ T cells: a potential player in renal fibrosis
DJ Nikolic-Paterson - Kidney international, 2010 - Elsevier
Kidney international, 2010•Elsevier
T cells have a well-described role in renal injury, which leads to the secondary development
of renal fibrosis. It has generally been assumed that this fibrotic response is an indirect
consequence of T cell-mediated renal injury, rather than T cells' being directly involved in
fibrosis. Tapmeier et al. now provide evidence that CD4+ T cells promote interstitial fibrosis
in the obstructed mouse kidney in a mechanism that appears to dissociate myofibroblast
accumulation and matrix deposition.
of renal fibrosis. It has generally been assumed that this fibrotic response is an indirect
consequence of T cell-mediated renal injury, rather than T cells' being directly involved in
fibrosis. Tapmeier et al. now provide evidence that CD4+ T cells promote interstitial fibrosis
in the obstructed mouse kidney in a mechanism that appears to dissociate myofibroblast
accumulation and matrix deposition.
T cells have a well-described role in renal injury, which leads to the secondary development of renal fibrosis. It has generally been assumed that this fibrotic response is an indirect consequence of T cell-mediated renal injury, rather than T cells’ being directly involved in fibrosis. Tapmeier et al. now provide evidence that CD4+ T cells promote interstitial fibrosis in the obstructed mouse kidney in a mechanism that appears to dissociate myofibroblast accumulation and matrix deposition.
Elsevier