Role of nitric oxide and prostanoids in the regulation of leg blood flow and blood pressure in humans with essential hypertension: effect of high‐intensity aerobic …
M Nyberg, LG Jensen, P Thaning… - The Journal of …, 2012 - Wiley Online Library
M Nyberg, LG Jensen, P Thaning, Y Hellsten, SP Mortensen
The Journal of physiology, 2012•Wiley Online LibraryKey points• Nitric oxide and prostanoids are substances that dilate the blood vessels. We
examined the role of these vasodilators in the regulation of blood flow to contracting muscle
and systemic blood pressure before and after a training intervention in subjects with
essential hypertension and in healthy controls.• We show that blood flow to the exercising
leg is lower in essential hypertension.• Surprisingly, this effect on blood flow is not the result
of a reduced capacity of the nitric oxide and prostanoid systems to dilate the blood vessels; …
examined the role of these vasodilators in the regulation of blood flow to contracting muscle
and systemic blood pressure before and after a training intervention in subjects with
essential hypertension and in healthy controls.• We show that blood flow to the exercising
leg is lower in essential hypertension.• Surprisingly, this effect on blood flow is not the result
of a reduced capacity of the nitric oxide and prostanoid systems to dilate the blood vessels; …
Key points
- • Nitric oxide and prostanoids are substances that dilate the blood vessels. We examined the role of these vasodilators in the regulation of blood flow to contracting muscle and systemic blood pressure before and after a training intervention in subjects with essential hypertension and in healthy controls.
- • We show that blood flow to the exercising leg is lower in essential hypertension.
- • Surprisingly, this effect on blood flow is not the result of a reduced capacity of the nitric oxide and prostanoid systems to dilate the blood vessels; however, these systems do appear to play a role in the training induced reduction in blood pressure.
- • These findings advance our understanding of vascular dysfunction associated with essential hypertension and the mechanisms underlying the blood pressure reducing effect of exercise.
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