Signal transduction mechanisms mediating the physiological and pathophysiological actions of angiotensin II in vascular smooth muscle cells
RM Touyz, EL Schiffrin - Pharmacological reviews, 2000 - Elsevier
Until recently, the signaling events elicited in vascular smooth muscle cells by angiotensin II
(Ang II) were considered to be rapid, short-lived, and divided into separate linear pathways,
where intracellular targets of the phospholipase C-diacylglycerol-Ca 2+ axis were distinct
from those of the tyrosine kinase-and mitogen-activated protein kinase-dependent
pathways. However, these major intracellular signaling cascades do not function
independently and are actively engaged in cross-talk. Downstream signals from the Ang II …
(Ang II) were considered to be rapid, short-lived, and divided into separate linear pathways,
where intracellular targets of the phospholipase C-diacylglycerol-Ca 2+ axis were distinct
from those of the tyrosine kinase-and mitogen-activated protein kinase-dependent
pathways. However, these major intracellular signaling cascades do not function
independently and are actively engaged in cross-talk. Downstream signals from the Ang II …
