The ectodomain shedding of syndecan-1, a major cell surface heparan sulfate proteoglycan,
modulates molecular and cellular processes central to the pathogenesis of inflammatory
diseases. Syndecan-1 shedding is a highly regulated process in which outside-in signaling
accelerates the proteolytic cleavage of syndecan-1 ectodomains at the cell surface. Several
extracellular agonists that induce syndecan-1 shedding and metalloproteinases that cleave
syndecan-1 ectodomains have been identified, but the intracellular mechanisms that …