Antigen presentation by CD1: lipids, T cells, and NKT cells in microbial immunity
NR Cohen, S Garg, MB Brenner - Advances in immunology, 2009 - Elsevier
The discovery of molecules capable of presenting lipid antigens, the CD1 family, and of the
T cells that recognize them, has opened a new dimensionin our understanding of cell-
mediated immunity against infection. Like MHC Class I molecules, CD1 isoforms (CD1a, b, c
and d) are assembled in the ER and sent to the cell surface. However, in contrast to MHC
molecules, CD1 complexes are then re-internalized into specific endocytic compartments
where they can bind lipid antigens. These include a broad scope of both self and foreign …
T cells that recognize them, has opened a new dimensionin our understanding of cell-
mediated immunity against infection. Like MHC Class I molecules, CD1 isoforms (CD1a, b, c
and d) are assembled in the ER and sent to the cell surface. However, in contrast to MHC
molecules, CD1 complexes are then re-internalized into specific endocytic compartments
where they can bind lipid antigens. These include a broad scope of both self and foreign …