[HTML][HTML] Extraordinary GU-rich single-strand RNA identified from SARS coronavirus contributes an excessive innate immune response
Y Li, M Chen, H Cao, Y Zhu, J Zheng, H Zhou - Microbes and infection, 2013 - Elsevier
A dangerous cytokine storm occurs in the SARS involving in immune disorder, but many
aspects of the pathogenetic mechanism remain obscure since its outbreak. To deeply reveal
the interaction of host and SARS-CoV, based on the basic structural feature of pathogen-
associated molecular pattern, we created a new bioinformatics method for searching
potential pathogenic molecules and identified a set of SARS-CoV specific GU-rich ssRNA
fragments with a high-density distribution in the genome. In vitro experiments, the result …
aspects of the pathogenetic mechanism remain obscure since its outbreak. To deeply reveal
the interaction of host and SARS-CoV, based on the basic structural feature of pathogen-
associated molecular pattern, we created a new bioinformatics method for searching
potential pathogenic molecules and identified a set of SARS-CoV specific GU-rich ssRNA
fragments with a high-density distribution in the genome. In vitro experiments, the result …
