Assessing neurodegenerative phenotypes in Drosophila dopaminergic neurons by climbing assays and whole brain immunostaining
MC Barone, D Bohmann - JoVE (Journal of Visualized Experiments), 2013 - jove.com
Drosophila melanogaster is a valuable model organism to study aging and pathological
degenerative processes in the nervous system. The advantages of the fly as an
experimental system include its genetic tractability, short life span and the possibility to
observe and quantitatively analyze complex behaviors. The expression of disease-linked
genes in specific neuronal populations of the Drosophila brain, can be used to model
human neurodegenerative diseases such as Parkinson's and Alzheimer's 5. Dopaminergic …
degenerative processes in the nervous system. The advantages of the fly as an
experimental system include its genetic tractability, short life span and the possibility to
observe and quantitatively analyze complex behaviors. The expression of disease-linked
genes in specific neuronal populations of the Drosophila brain, can be used to model
human neurodegenerative diseases such as Parkinson's and Alzheimer's 5. Dopaminergic …