Assessment of dopaminergic homeostasis in mice by use of high-performance liquid chromatography analysis and synaptosomal dopamine uptake
Dopamine (DA) is a modulatory neurotransmitter controlling motor activity, reward processes
and cognitive function. Impairment of dopaminergic (DAergic) neurotransmission is strongly
associated with several central nervous system-associated diseases such as Parkinson's
disease, attention-deficit-hyperactivity disorder and drug addiction1, 2, 3, 4. Delineating
disease mechanisms involving DA imbalance is critically dependent on animal models to
mimic aspects of the diseases, and thus protocols that assess specific parts of the DA …
and cognitive function. Impairment of dopaminergic (DAergic) neurotransmission is strongly
associated with several central nervous system-associated diseases such as Parkinson's
disease, attention-deficit-hyperactivity disorder and drug addiction1, 2, 3, 4. Delineating
disease mechanisms involving DA imbalance is critically dependent on animal models to
mimic aspects of the diseases, and thus protocols that assess specific parts of the DA …
