[HTML][HTML] Oligomerization and trafficking of the human dopamine transporter: mutational analysis identifies critical domains important for the functional expression of the …
The dopamine transporter (DAT) is a presynaptic plasma membrane protein responsible for
the termination of dopaminergic neurotransmission in the central nervous system. While
most studies have focused on structure/function analysis, much less information is available
regarding the assembly and the trafficking of this protein. To address this problem, we
performed a mutational analysis of the DAT protein, combined with biochemical,
immunological, and functional approaches. In mammalian cells co-expressing differentially …
the termination of dopaminergic neurotransmission in the central nervous system. While
most studies have focused on structure/function analysis, much less information is available
regarding the assembly and the trafficking of this protein. To address this problem, we
performed a mutational analysis of the DAT protein, combined with biochemical,
immunological, and functional approaches. In mammalian cells co-expressing differentially …