[HTML][HTML] Hepatic hepcidin expression is decreased in cirrhosis and HCC
SM Kessler, S Laggai, AK Kiemer… - Journal of …, 2015 - journal-of-hepatology.eu
Furthermore, Hamp mRNA levels were even lower in tumor tissue (Fig. 1 D and E).
Interestingly, hepatitis C virus (HCV) has been described to suppress hepcidin expression
via generation of reactive oxygen species [8]. With HBV also inducing oxidant stress, this
might also be true for HBV. Furthermore, Hamp expression can be transcriptionally activated
by the tumor suppressor p53 [9]. As p53 is frequently suppressed in HCC [10],
downregulation of hepcidin might be linked to p53 suppression. In conclusion, these …
Interestingly, hepatitis C virus (HCV) has been described to suppress hepcidin expression
via generation of reactive oxygen species [8]. With HBV also inducing oxidant stress, this
might also be true for HBV. Furthermore, Hamp expression can be transcriptionally activated
by the tumor suppressor p53 [9]. As p53 is frequently suppressed in HCC [10],
downregulation of hepcidin might be linked to p53 suppression. In conclusion, these …
