[HTML][HTML] ATF4 protein deficiency protects against high fructose-induced hypertriglyceridemia in mice
G Xiao, T Zhang, S Yu, S Lee… - Journal of biological …, 2013 - ASBMB
Hypertriglyceridemia is the most common lipid disorder in obesity and type 2 diabetes. It
results from increased production and/or decreased clearance of triglyceride-rich
lipoproteins. To better understand the pathophysiology of hypertriglyceridemia, we studied
hepatic regulation of triglyceride metabolism by the activating transcription factor 4 (ATF4), a
member of the basic leucine zipper-containing protein subfamily. We determined the effect
of ATF4 on hepatic lipid metabolism in Atf4−/− mice fed regular chow or provided with free …
results from increased production and/or decreased clearance of triglyceride-rich
lipoproteins. To better understand the pathophysiology of hypertriglyceridemia, we studied
hepatic regulation of triglyceride metabolism by the activating transcription factor 4 (ATF4), a
member of the basic leucine zipper-containing protein subfamily. We determined the effect
of ATF4 on hepatic lipid metabolism in Atf4−/− mice fed regular chow or provided with free …