[HTML][HTML] Expression, localization, and biochemical characterization of nicotinamide mononucleotide adenylyltransferase 2
PR Mayer, N Huang, CM Dewey, DR Dries… - Journal of Biological …, 2010 - ASBMB
Nicotinamide mononucleotide (NMN) adenylyltransferase 2 (Nmnat2) catalyzes the
synthesis of NAD from NMN and ATP. The Nmnat2 transcript is expressed predominately in
the brain; we report here that Nmnat2 is a low abundance protein expressed in neurons.
Previous studies indicate that Nmnat2 localizes to Golgi. As Nmnat2 is not predicted to
contain a signal sequence, lipid-binding domain, or transmembrane domain, we
investigated the nature of this interaction. These experiments reveal that Nmnat2 is …
synthesis of NAD from NMN and ATP. The Nmnat2 transcript is expressed predominately in
the brain; we report here that Nmnat2 is a low abundance protein expressed in neurons.
Previous studies indicate that Nmnat2 localizes to Golgi. As Nmnat2 is not predicted to
contain a signal sequence, lipid-binding domain, or transmembrane domain, we
investigated the nature of this interaction. These experiments reveal that Nmnat2 is …