[HTML][HTML] The Hybrid Mouse Diversity Panel: a resource for systems genetics analyses of metabolic and cardiovascular traits
AJ Lusis, MM Seldin, H Allayee, BJ Bennett… - Journal of lipid …, 2016 - ASBMB
The Hybrid Mouse Diversity Panel (HMDP) is a collection of approximately 100 well-
characterized inbred strains of mice that can be used to analyze the genetic and
environmental factors underlying complex traits. While not nearly as powerful for mapping
genetic loci contributing to the traits as human genome-wide association studies, it has
some important advantages. First, environmental factors can be controlled. Second, relevant
tissues are accessible for global molecular phenotyping. Finally, because inbred strains are …
characterized inbred strains of mice that can be used to analyze the genetic and
environmental factors underlying complex traits. While not nearly as powerful for mapping
genetic loci contributing to the traits as human genome-wide association studies, it has
some important advantages. First, environmental factors can be controlled. Second, relevant
tissues are accessible for global molecular phenotyping. Finally, because inbred strains are …