High expression of DDR1 is associated with the poor prognosis in Chinese patients with pancreatic ductal adenocarcinoma
Y Huo, M Yang, W Liu, J Yang, X Fu, D Liu, J Li… - Journal of Experimental …, 2015 - Springer
Y Huo, M Yang, W Liu, J Yang, X Fu, D Liu, J Li, J Zhang, R Hua, Y Sun
Journal of Experimental & Clinical Cancer Research, 2015•SpringerBackground Discoidin domain receptors 1 (DDR1), a subtype of DDRs, has been reported
as a critical modulator of cellular morphogenesis, differentiation, migration and invasion.
Methods and results In this study, we investigated the expression of DDR1 and its clinical
association in Chinese patients with pancreatic ductal adenocarcinoma (PDAC). Across a
cohort of 30 patients, we examined DDR1 expression in paired PDAC and corresponding
adjacent non-tumor tissues by real-time quantitative PCR (RT-qPCR), or western blotting …
as a critical modulator of cellular morphogenesis, differentiation, migration and invasion.
Methods and results In this study, we investigated the expression of DDR1 and its clinical
association in Chinese patients with pancreatic ductal adenocarcinoma (PDAC). Across a
cohort of 30 patients, we examined DDR1 expression in paired PDAC and corresponding
adjacent non-tumor tissues by real-time quantitative PCR (RT-qPCR), or western blotting …
Background
Discoidin domain receptors 1 (DDR1), a subtype of DDRs, has been reported as a critical modulator of cellular morphogenesis, differentiation, migration and invasion.
Methods and results
In this study, we investigated the expression of DDR1 and its clinical association in Chinese patients with pancreatic ductal adenocarcinoma (PDAC). Across a cohort of 30 patients, we examined DDR1 expression in paired PDAC and corresponding adjacent non-tumor tissues by real-time quantitative PCR (RT-qPCR), or western blotting. DDR1 expression is significantly higher in PDAC, as compared to normal adjacent tissue, confirming results from the Oncomine databases. We validated DDR1 expression by immunohistochemistry across a non-overlapping cohort of 205 PDAC specimens. Kaplan-Meier survival curves indicate that increased expression of DDR1 is associated with a poor prognosis in PDAC patients (P = 0.013). Multivariate Cox regression analysis identified DDR1 expression, age, N classification and liver metastasis as independent prognostic factors in PDAC.
Conclusions
This study demonstrated that DDR1 can well serve as a novel prognostic biomarker in PDAC.
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