Reply to Hernandez et al.-GWAS of acute renal graft rejection
A Massart, L Ghisdal, O Viklicky… - American Journal of …, 2018 - amjtransplant.org
Hernandez et al recently reported on several large genomewide association studies
(GWAS) in kidney transplantation. 1 In particular, they investigated the effect of either donor
single nucleotide polymorphisms (SNPs), recipient SNPs, or combined donor-recipient
SNPs on graft survival and acute rejection. Despite impressive patient numbers, no SNP
signal emerged. The authors concluded that “both phenotype heterogeneity and sample
size may have contributed.” We sought to understand the lack of genetic association with …
(GWAS) in kidney transplantation. 1 In particular, they investigated the effect of either donor
single nucleotide polymorphisms (SNPs), recipient SNPs, or combined donor-recipient
SNPs on graft survival and acute rejection. Despite impressive patient numbers, no SNP
signal emerged. The authors concluded that “both phenotype heterogeneity and sample
size may have contributed.” We sought to understand the lack of genetic association with …
