The loss of IgM memory B cells correlates with clinical disease in common variable immunodeficiency
R Carsetti, MM Rosado, S Donnanno, V Guazzi… - Journal of Allergy and …, 2005 - Elsevier
BACKGROUND: Recurrent lower respiratory tract infections caused by encapsulated
bacteria might cause permanent organ damage in patients with common variable
immunodeficiency (CVID). Despite the profound hypogammaglobulinemia, some patients do
not experience bacterial pneumonia. We have shown that IgM memory B cells and natural
antibodies play an important role in the defense against encapsulated bacteria. OBJECTIVE:
In this study we addressed the question of whether the apparent paradox of patients with …
bacteria might cause permanent organ damage in patients with common variable
immunodeficiency (CVID). Despite the profound hypogammaglobulinemia, some patients do
not experience bacterial pneumonia. We have shown that IgM memory B cells and natural
antibodies play an important role in the defense against encapsulated bacteria. OBJECTIVE:
In this study we addressed the question of whether the apparent paradox of patients with …