Heterozygosity for transmembrane activator and calcium modulator ligand interactor A144E causes haploinsufficiency and pneumococcal susceptibility in mice
HH Jabara, JJ Lee, E Janssen, S Ullas… - Journal of Allergy and …, 2017 - Elsevier
Background The B-cell receptor transmembrane activator and calcium modulator ligand
interactor (TACI) is important for T-independent antibody responses. One in 200 blood
donors are heterozygous for the TACI A181E mutation. Objective We sought to investigate
the effect on B-cell function of TACI A181E heterozygosity in reportedly healthy subjects and
of the corresponding TACI A144E mutation in mice. Methods Nuclear factor κB (NF-κB)
activation was measured by using the luciferase assay in 293T cells cotransfected with wild …
interactor (TACI) is important for T-independent antibody responses. One in 200 blood
donors are heterozygous for the TACI A181E mutation. Objective We sought to investigate
the effect on B-cell function of TACI A181E heterozygosity in reportedly healthy subjects and
of the corresponding TACI A144E mutation in mice. Methods Nuclear factor κB (NF-κB)
activation was measured by using the luciferase assay in 293T cells cotransfected with wild …