The genetic and antigenic basis of tumour transplantation.

PA Gorer - 1937 - cabidigitallibrary.org
PA Gorer
1937cabidigitallibrary.org
THE material consisted of 2 pure lines of mice, black and albino, of which the latter
possesses an antigen (antigen II), based on a single dominant gene. An F1; both back-
crosses and an F2 were raised and experiments were made with grafts of a sarcoma which
arose in the albino strain. All albinos, F1 and albino backcross animals inoculated were
susceptible, while none of the black (45 cases) developed the tumour. In the F2, the ratio of
susceptible: resistant was 1: 1, and in the black backcross, roughly 1: 3. The proportions of …
Abstract
THE material consisted of 2 pure lines of mice, black and albino, of which the latter possesses an antigen (antigen II), based on a single dominant gene. An F1; both back-crosses and an F2 were raised and experiments were made with grafts of a sarcoma which arose in the albino strain. All albinos, F1 and albino backcross animals inoculated were susceptible, while none of the black (45 cases) developed the tumour. In the F2, the ratio of susceptible: resistant was 1: 1, and in the black backcross, roughly 1: 3. The proportions of animals with or without antigen II were the same and in both cases all the susceptibles carried the antigen. These results are interpreted as indicating that susceptibility to the tumour is based on 2 (possibly 3) dominant genes, one of which appears to be identical with that determining the presence of antigen II.
CABI Digital Library